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In the US, obesity rates declined from nearly 40% in 2021 to 37% in 2025, according to a large Gallup poll
Additionally, GLP-1 therapies suppress glucagon, a hormone that normally elevates blood sugar, further enhancing glucose regulation
This adaptation makes continued weight loss progressively harder and weight regain increasingly likely
Compounded tirzepatide, on the other hand, is not FDA-approved
The article names people with baseline gastrointestinal sensitivity, diabetes requiring insulin, liver disease, or a history of alcohol use disorder as facing higher risk
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