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Model Systems: Suitable for rodent models (e.g., diet-induced obese mice), cell cultures (e.g., adipocytes, hepatocytes), or organoid systems studying metabolic pathways
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Structural equivalence is typically confirmed through comparative peptide mapping experiments
All drugs followed a similar trend in which the calculated circulating concentration of the drug at stead state (C ss ) exhibits significant positive association with body weight loss ( Figure 1D )
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In one study, BSO treatment alleviated ethanol-induced elevations in serum ALT and liver TG content 15
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