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Serine (Ser) can be obtained exogenously or synthesized from glycolytic intermediates through the serine synthesis pathway, in which 3-phosphoglycerate dehydrogenase (PHGDH) is the key rate-limiting step (64)
K.et al (2009)
However, similar to GnRH agonist, GnRH antagonist is associated with hypoestrogenic adverse effects, which require the addition of estradiol and norethindrone acetate (add-back therapy) to attenuate the hypoestrogenic effect (Schlaff et al., 2020)
Currently this technique is used for musculoskeletal injuries and chronic arthritis
Kraemer WJ et al
M.Le TrongI.KrippsK
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