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Altogether, these data support a pathogenicity mechanism where variants can disrupt transporter gating
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Experimental studies demonstrated that modulation of NNMT pathways could influence metabolic signaling networks involved in cellular energy utilization and body composition regulation
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10.1186/1471-2407-14-621 180 MetalloC
Subsequently, SOX8 targets HK2 and lactate dehydrogenase (LDHA), which affect the glycolysis process via the SOX8/FOXK1 axis, ultimately leading to drug resistance ( Table 1 ) Table 1 The alternation of molecules or pathways
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