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Six type 1 diabetic males and six age-, sex-, and body mass index-matched control volunteers were studied

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IRS recruitment activates phosphoinositide 3-kinase (PI3K), which phosphorylates PIP2 to PIP3, recruiting Akt/PKB to the membrane for activation by PDK1 this PI3K/Akt arm drives protein synthesis via mTORC1, glucose uptake via GLUT4 translocation, and cell survival via BAD phosphorylation

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