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14 (9), e29696

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Gene ontology analysis using the DAVID tool, focusing on the genes upregulated by pefloxacin and whose upregulation was suppressed by dexamethasone co-administration, revealed that several pathways related to oxidative stress, such as response to hydrogen peroxide and hydrogen peroxide catabolic process, were enriched (Figure 5A)

fumigatus (Vicentefranqueira et al., 2018, 2019), although the presence of two ZR-like motifs (i.e., Z inc R esponse consensus motifs) at 2000 and 1272 bp upstream the translation start codon (TSC) of metR and a ZR-like motif at 318 bp upstream the TSC of cysB indicates that a direct ZafA-mediated repression of these genes is possible

So, it's that really very dramatic change that happens in the early 2000s