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Current clinical trials and future studies should take into account gender-dependent factors, receptor polymorphism, and the selectivity of brain regions in order to optimize the translational potential of this strategy [114]

3.4 Changes in serum homocysteine by supplementation route and dosage Analysis of 10 comparisons showed that vitamin B12 supplementation was associated with a mean reduction of 35.8% in serum homocysteine concentrations (Supplementary Table S5)

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It may offer neuroprotective, angiogenic, wound healing and tissue growth propertiesand all of these benefits have been noted in preclinical studies, although human research is severely lacking

ncbi.nlm.nih.gov/pmc/articles/PMC5397288/ #2

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