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Here are some potential risks and benefits

Medical appropriateness varies by patient

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That distinction targeted fat pathway versus systemic GH-axis stimulation is the core of why researchers choose one over the other, and it shapes everything from their evidence base to their regulatory status

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That is a different story from spacing doses under supervision. What structured de-escalation is and what it is not The authors described reduced-frequency maintenance as structured de-escalation that could reduce treatment burden without sacrificing key outcomes, at least in selected patients