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Some patients feel the effect almost immediately after starting the medication, says Jessica Bartfield, M.D., an obesity medicine physician and associate professor at Wake Forest University School of Medicine who specializes in medical weight management

These shifts reflect a deeper change: a reorientation of consumption around health and wellness

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Systemic effects reported or plausibly linked to elevated growth hormone and IGF-1 include water retention, tingling or numbness (paresthesia), joint discomfort, headache, flushing, and transient changes in glucose handling

The majority of developed countries, including the United States, Canada and England are experiencing dramatic increases in obesity