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Treatment considerations include: Concurrent folate supplementation if deficient (never give folate alone, as it may precipitate neurological deterioration) Potassium monitoring during initial treatment in severe anaemia or at-risk patients (e.g., those with heart failure) Response assessment: reticulocyte count peaks at 57 days, haemoglobin normalises within 68 weeks Neurological symptoms may take 612 months to improve and may not fully resolve Patients should be advised that treatment for pernicious anaemia or post-surgical deficiency is lifelong

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5-Amino-1MQ split AM/PM | 1216 weeks on, 68 weeks off | Long-term body composition studies, aging research, mitochondrial biogenesis observation | Lower doses extend research duration and reduce acute side effect profiles, ideal for longitudinal studies

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CMS confirms it valid for the 2026 code year

Rising liver enzymes warrant further investigation