Psychological disorders such as Alzheimer's disease have been shown to cause oxidative damage to glycolytic enzymes as well as enzymes involved in the tricarboxylic cycle during glucose metabolism, thereby affective ATP biogenesis (169)
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Three groups of physicians independently found this: Biochemical Institute, University of Copenhagen (Dam and Johannes Glavind), University of Iowa Department of Pathology (Emory Warner, Kenneth Brinkhous, and Harry Pratt Smith), and the Mayo Clinic (Hugh Butt, Albert Snell, and Arnold Osterberg)
Kolega, Z
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PDB codes of previously published structures used in this study are 4HJE (human p53 DBD), 3L2C (human FOXO4 FH domain bound to DNA) and 1E17 (human FOXO4 FH domain)